Population Genetics & Genomics

From DNA variation to disease causality — a different mindset from expression.

Lessons

03-01 · Variant Annotation

Annotate VCF variants with function, clinical significance and pathogenicity.

03-02 · GWAS to Function (TWAS)

From GWAS to causal genes via TWAS, colocalization and MR.

03-03 · Mendelian Randomization

Genetic variants as instruments to infer causal effects.

03-04 · Polygenic Risk Score

Compute PRS from PGS Catalog weights — no GWAS needed.